Acetone → 3-Butyl-6-(isopropylamino)-phthalide

HRID 2120183

반응식

HRID 2120183 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[CH3:16][C:17]([CH3:19])=O>C(O)C.[Pd]>[CH2:12]([CH:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][CH:17]([CH3:19])[CH3:16])=[CH:3][CH:4]=2)[C:8](=[O:9])[O:7]1)[CH2:13][CH2:14][CH3:15]

참가 물질

5

반응물 2

HCID 180AcetoneHCID 98777066-Amino-3-butyl-phthalide

생성물 1

HCID 99648533-Butyl-6-(isopropylamino)-phthalide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 4.1 g (20.0 mmol) of compound obtained in Example 4 in 4 ml of acetone and 96 ml of anhydrous ethanol there is added 10% Pd—C catalyst. The mixture is hydrogenated under a hydrogen pressure of 3-3.5 kg/cm2. After the absorption of hydrogen is complete, the catalyst is filtered off and the filtrate is concentrated in vacuo to dryness. The residue is crystallised from dilute ethanol to give the title compound.

후처리

  1. customAfter the absorption of hydrogen
  2. filtrationthe catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo to dryness
  4. customThe residue is crystallised from dilute ethanol

출처 및 근거

ORD 기록
ord-8484c0784fa546faa001dddbf1c438e2
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06689808B2

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