Salicylaldehyde → 3-(2-Hydroxybenzylidene)-6-thiophen-3-yl-1,3-dihydroindol-2-one

HRID 2120200

반응식

HRID 2120200 반응식
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:14]=[C:13]3[C:9]([CH2:10][C:11](=[O:15])[NH:12]3)=[CH:8][CH:7]=2)=[CH:2]1.[OH:16][C:17]1[CH:24]=[CH:23][CH:22]=[CH:21][C:18]=1[CH:19]=O.N1CCCCC1>C(O)C>[OH:16][C:17]1[CH:24]=[CH:23][CH:22]=[CH:21][C:18]=1[CH:19]=[C:10]1[C:9]2[C:13](=[CH:14][C:6]([C:3]3[CH:4]=[CH:5][S:1][CH:2]=3)=[CH:7][CH:8]=2)[NH:12][C:11]1=[O:15]

참가 물질

5

반응물 3

HCID 6998SalicylaldehydeHCID 8082PiperidineHCID 234390276-Thiophen-3-yl-1,3-dihydroindol-2-one

생성물 1

HCID 536743653-(2-Hydroxybenzylidene)-6-thiophen-3-yl-1,3-dihydroindol-2-one수율 69%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 6-thiophen-3-yl-1,3-dihydroindol-2-one (100 mg, 0.5 mmol), 2-hyroxy-benzaldehyde (60 mg, 0.5 mmol) and piperidine (0.23 mL) in ethanol (4 mL) was stirred at reflux overnight. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 110 mg (69%) of 3-(2-hydroxybenzylidene)-6-thiophen-3-yl-1,3-dihydroindol-2-one as yellow-red crystals.

후처리

  1. temperatureat reflux overnight
  2. filtrationThe precipitate was collected by vacuum filtration
  3. washwashed with ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-810dfb8b26d54e3086376f582cc18ff8
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06689806B1

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