Ethyl ketone → 1-(Dimethylamino)-2-methylpent-1-en-3-one

반응식

[CH2:1]([C:3]([CH2:5][CH3:6])=[O:4])[CH3:2].[Cl-].[CH3:8][N:9]([CH3:16])[CH:10]=NC=[N+](C)C.C[O-].[Na+]>CO>[CH3:8][N:9]([CH3:16])[CH:10]=[C:1]([CH3:2])[C:3](=[O:4])[CH2:5][CH3:6]

참가 물질

실험 절차

Diethyl ketone (29.71 g; 0.345 mol) and [3-(dimethylamino)-2-azaprop-2-en-1-ylidene]dimethyl-ammonium chloride (37.64 g; 0.230 mol) were added to a solution of 30% of sodium methoxide in methanol (41.41 g; 0.230 mol) and methanol (305 ml) at 20° C. under N2. The reaction mixture was refluxed for 18 h and then concentrated under reduced pressure. The residue was dissolved in dichloromethane (300 ml) and washed with saturated sodium bisulphite solution (3×100 ml). The organic phase was dried over Na2SO4 and concentrated under reduced pressure. This gave 26.60 g of product, which comprised 42% by weight of 1-(dimethylamino)-2-methylpent-1-en-3-one (corresponding to a yield of 34%).