Sodium Carbonate → 4-Amino-2,3-dichlorophenyl thiocyanate

HRID 2120365노트

반응식

HRID 2120365 반응식
[Cl:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[S-:10][C:11]#[N:12].[Na+].BrBr.[Br-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([S:10][C:11]#[N:12])[CH:6]=[CH:5][C:3]=1[NH2:4]

참가 물질

8

반응물 5

HCID 10340Sodium CarbonateHCID 118442,3-DichloroanilineHCID 24408BromineHCID 253881Sodium BromideHCID 516871Sodium thiocyanate

생성물 1

HCID 146019304-Amino-2,3-dichlorophenyl thiocyanate수율 88%

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

실험 절차

To a cold (0-5° C.) solution of 2,3-dichloroaniline (2 g) and sodium thiocyanate (3 g) in MeOH (30 ml), was added a solution of bromine (2 g) in MeOH (10 ml) saturated with sodium bromide. The solution was left to stir for 1 hour. The reaction mixture was poured into water (200 ml) and neutralised with sodium carbonate to pH 8. The solid was collected by filtration and dried to yield the title compound as a white solid (2.38 g) 88%. NMR: 6.35 (s, 2H), 6.81 (d, 1H), 7.55 (d, 1H); m/z (EI+): 218.

후처리

  1. waitThe solution was left
  2. filtrationThe solid was collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-600422e8e40042edadd21a0ca46711ee
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06689909B1

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