Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-Methyl-3-phenylisoxazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 5-methyl-3-phenyl-1,2-oxazole-4-carboxylate | HCID 727920 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Methyl-3-phenylisoxazole-4-carboxylic acid | HCID 14343 | 72% |
반응 단계
To 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (0.853 g, 3.69 mmol) in methanol (12 mL) was added 2N NaOH (8 mL) the reaction solution was stirred at ambient temperature for 60 hr. The solution was dilute with water and extracted twice with ethyl acetate. The combined extract was washed with brine and dried over MgSO4 and concentrated. Recrystallization (hexanes/ethyl acetate) afforded a white solid (0.540 g, 72% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06693108B2 |
| 출처 데이터셋 | uspto-grants-2004_02 |
| ORD ID | ord-759782c99ed64ee299dbfffe8399244d |
| 출처 메모 | uspto-grants-2004_02 |