反应详情

To 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (0.853 g, 3.69 mmol) in methanol (12 mL) was added 2N NaOH (8 mL) the reaction solution was stirred at ambient temperature for 60 hr. The solution was dilute with water and extracted twice with ethyl acetate. The combined extract was washed with brine and dried over MgSO4 and concentrated. Recrystallization (hexanes/ethyl acetate) afforded a white solid (0.540 g, 72% yield).

1. extractionextracted twice with ethyl acetate
2. extractionThe combined extract
3. washwas washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customRecrystallization (hexanes/ethyl acetate)