Sodium Hydroxide → HCID 22247174, 화합물

HRID 2121862노트

반응식

HRID 2121862 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:22]=[O:23])=[C:13]([N:15]([CH2:18][CH:19]([OH:21])[CH3:20])C=O)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C1COCC1>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:22]=[O:23])=[C:13]([NH:15][CH2:18][CH:19]([OH:21])[CH3:20])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22247178N-(5-Benzyloxy-2-formylphenyl)-N-(2-hydroxypropyl)-formamide

생성물 1

HCID 22247174HCID 22247174, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

An ice-cooled solution of the product from Step B (298 g, 0.95 mol) in THF (3 L) was treated with 1 M aqueous sodium hydroxide (1.95 L, 1.9 mol) keeping the temperature below 8° C. After the starting material was consumed, the mixture was diluted with brine and extracted twice with ethyl ether. The organic solution was washed with water until neutral and then with brine, dried over sodium sulfate, treated with charcoal and passed through silica (1 kg) with ether and with 1:1 ethyl acetate-hexane to yield, after concentration in vacuo, a yellow solid (207 g, 76%).

후처리

  1. customthe temperature below 8° C
  2. customAfter the starting material was consumed
  3. additionthe mixture was diluted with brine
  4. extractionextracted twice with ethyl ether
  5. washThe organic solution was washed with water until neutral and then with brine
  6. dry with materialdried over sodium sulfate
  7. additiontreated with charcoal
  8. customto yield
  9. concentrationafter concentration in vacuo

출처 및 근거

ORD 기록
ord-054df37d290844e1b540be7e8c8bdcc9
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06696476B2

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