Acetic Anhydride → N-(4-Chloro-3-nitrophenyl)acetamide

HRID 2122014노트

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HRID 2122014 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 124774-Chloro-3-nitroaniline

생성물 1

HCID 79672N-(4-Chloro-3-nitrophenyl)acetamide수율 101.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 4-chloro-3-nitroaniline (51.8 g, 0.36 mol) in anhydrous DCM (300 mL) was added dropwise acetic anhydride (45 mL, 0.48 mol) at room temperature, and the resulting solution was stirred at room temperature for 3 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitates were collected by filtration, washed thoroughly with Et2O, and dried under high vacuum to give 4′-chloro-3′-nitroacetanilide (78.7 g, 100%).

후처리

  1. customThe solvent was removed in vacuo, and Et2O
  2. additionwas added to the residue
  3. filtrationThe precipitates were collected by filtration
  4. washwashed thoroughly with Et2O
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-24d14610b97d416dba3a9ee226a36e56
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06696473B2

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