Methanol → E-5-Decen-1-ol

HRID 2122093

반응식

HRID 2122093 반응식
C([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH3:14])(=O)C.CO.[OH-].[Na+]>CCCCCC>[CH2:5]([OH:4])[CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 38027Dec-5-enyl acetate

생성물 1

HCID 92458E-5-Decen-1-ol수율 89.8%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

A portion of the 5-decenyl acetate can be removed and converted to the corresponding alcohol according to the following procedure and the scale can be adjusted as necessary. 15.0 g (67 mmol) of the 5-decenyl acetate, 35 mL of methanol and 34 mL of 2 M sodium hydroxide are added to a 250 mL round-bottomed flask. This mixture is stirred for three hours at room temperature. After three hours the hydrolysis is complete, 10 mL of hexane is then added and the solution is washed with 10 mL of 1 M HCl, 10 mL of NaHCO3-saturated water and 10 mL of brine. The organic phase is dried with sodium sulfate and filtered, and the hexane is removed under reduced pressure to yield 9.4 g of 5-decenol. GC analysis shows the isometric ratio of the 5-decenol to be conserved.

후처리

  1. customA portion of the 5-decenyl acetate can be removed
  2. waitAfter three hours the hydrolysis is complete
  3. washthe solution is washed with 10 mL of 1 M HCl, 10 mL of NaHCO3-saturated water and 10 mL of brine
  4. dry with materialThe organic phase is dried with sodium sulfate
  5. filtrationfiltered
  6. customthe hexane is removed under reduced pressure

출처 및 근거

ORD 기록
ord-c7647988e84d4ec3a20388f0f5fedc24
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06696597B2

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