Triethylamine → 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide

HRID 21239

반응식

HRID 21239 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](Cl)=[O:6].[C:12]([NH2:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([NH:21][C:12]([CH3:14])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:13])=[O:6]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 27365483-Chloro-4-fluorobenzoyl Chloride

생성물 1

HCID 684919423-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide수율 97.1%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

In a similar manner to Step 1 of Example 16, 3-chloro-4-fluorobenzoyl chloride (3.00 g, 15.5 mmol) was dissolved in dichloromethane (60 mL), and the solution was treated with cumylamine (2.45 mL, 17.1 mmol), triethylamine (3.24 mL, 23.3 mmol) and DMAP (189 mg, 1.05 mmol), followed by purification by slurry using diisopropylether to obtain 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide (4.39 g, yield 97%).

후처리

  1. customfollowed by purification by slurry

출처 및 근거

ORD 기록
ord-ffb7690b8cdc47748458e2379a0e394f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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