Hydrogen Bromide → 3-Fluoro-4-hydroxybenzoic acid

HRID 21352노트

반응식

HRID 21352 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11]C)[C:5]([OH:7])=[O:6].Br>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 27334013-Fluoro-4-methoxybenzoic acid

생성물 1

HCID 1604563-Fluoro-4-hydroxybenzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Next, the 3-fluoro-4-methoxybenzoic acid (IV) was digested with HBr (20 ml) and glacial acetic acid (40 ml) overnight. Most of the acetic acid was distilled off and the remaining mixture was diluted with water. The precipitated benzoic acid was extracted in ether; the ether layer was dried, filtered and rotary evaporated to produce 11.0 g of the 3-fluoro-4-hydroxybenzoic acid (V).

후처리

  1. distillationMost of the acetic acid was distilled off
  2. additionthe remaining mixture was diluted with water
  3. extractionThe precipitated benzoic acid was extracted in ether
  4. dry with materialthe ether layer was dried
  5. filtrationfiltered
  6. customrotary evaporated

출처 및 근거

ORD 기록
ord-8e57d185e0ee46b387690b2c6fd8b245
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05422037

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