Sodium Hydroxide → N-(3-Hydroxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole

HRID 2141

반응식

HRID 2141 반응식
CS([O:5][C:6]1[CH:7]=[C:8]([S:14]([N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][CH2:18]2)(=[O:16])=[O:15])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13])(=O)=O.[OH-].[Na+]>>[OH:5][C:6]1[CH:7]=[C:8]([S:14]([N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][CH2:18]2)(=[O:16])=[O:15])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 19689647N-(3-methanesulphonyloxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole

생성물 1

HCID 19689638N-(3-Hydroxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole수율 100.5%

실험 절차

A solution of N-(3-methanesulphonyloxy-4-methoxybenzenesulphonyl)-1,2-dihydroindole (1 g) and saturated aqueous sodium hydroxide solution (2 ml) was heated at 85°-90° C. for 2 hours. The solvent was removed in vacuo and the residue partitioned between ethyl acetate (5 ml) and water (10 ml). The aqueous phase was acidified with 2N HCl and extracted with ethyl acetate (2×10 ml). The combined organic phases were dried over magnesium sulphate and concentrated in vacuo to yield a clear oil. Purification by column chromatography eluting with dichloromethane afforded the desired product as a white solid (0.8 g).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue partitioned between ethyl acetate (5 ml) and water (10 ml)
  3. extractionextracted with ethyl acetate (2×10 ml)
  4. dry with materialThe combined organic phases were dried over magnesium sulphate
  5. concentrationconcentrated in vacuo
  6. customto yield a clear oil
  7. customPurification by column chromatography
  8. washeluting with dichloromethane

출처 및 근거

ORD 기록
ord-ff57e297cfdc46e5b5870e456c42198a
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728712

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