Hydrochloric Acid → 2-Acetyl-4-methoxyphenyl 4-nitrobenzoate

HRID 215675

반응식

HRID 215675 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([OH:12])=[C:7]([C:9](=[O:11])[CH3:10])[CH:8]=1.[N+:13]([C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1)([O-:15])=[O:14].Cl>N1C=CC=CC=1>[C:9]([C:7]1[CH:8]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=1[O:12][C:20](=[O:21])[C:19]1[CH:18]=[CH:17][C:16]([N+:13]([O-:15])=[O:14])=[CH:24][CH:23]=1)(=[O:11])[CH3:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 85024-Nitrobenzoyl chlorideHCID 697141-(2-Hydroxy-5-methoxyphenyl)ethan-1-one

생성물 1

HCID 7760892-Acetyl-4-methoxyphenyl 4-nitrobenzoate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5′-methoxy-2′-hydroxyacetophenone (1.5 g, 9.03 mmol) was added to a pyridine solution (20 ml) that contained 4-nitrobenzoyl chloride (1.72 g, 9.26 mmol) in an ice bath. The obtained mixture was reacted at room temperature for 30 minutes, and the reaction solution was then poured into 1 N hydrochloric acid under cooling on ice. The obtained mixture was intensively stirred. The obtained precipitate was collected by filtration, and the filtrate was then washed with purified water, so as to obtain a product of interest, 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (compound 21). Yield: 2.49 g (yield constant: 87.4%)

후처리

  1. customThe obtained mixture was reacted at room temperature for 30 minutes
  2. temperatureunder cooling on ice
  3. filtrationThe obtained precipitate was collected by filtration
  4. washthe filtrate was then washed with purified water

출처 및 근거

ORD 기록
ord-0fda36c95d0a4a968ebfdb678629eeee
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08192717B2

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