Chloroform → N-allyl-5-azaisatoic anhydride

HRID 215790노트

반응식

HRID 215790 반응식
[C:1]12[C:7](=[CH:8][CH:9]=[N:10][CH:11]=1)[NH:6][C:5](=[O:12])[O:4][C:2]2=[O:3].[CH2:13](Br)[CH:14]=[CH2:15].C(N(CC)CC)C.C(Cl)(Cl)Cl>CN(C=O)C>[CH2:15]([N:6]1[C:5](=[O:12])[O:4][C:2](=[O:3])[C:1]2=[CH:11][N:10]=[CH:9][CH:8]=[C:7]12)[CH:14]=[CH2:13]

참가 물질

6

반응물 4

HCID 6212ChloroformHCID 7841Allyl bromideHCID 8471TriethylamineHCID 107970962H-Pyrido[4,3-d][1,3]oxazine-2,4(1H)-dione

생성물 1

HCID 86595201N-allyl-5-azaisatoic anhydride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 5-azaisatoic anhydride (1 mmol, Coppola, G. M. Synthesis 1980, 505) and allyl bromide (1.1 mmol) in DMF is added triethylamine (1.2 mmol) dropwise. The reaction mixture is allowed to stir at room temperature for 12 h after which time CHCl3 is added and the organic layer is washed with water, dried (MgSO4) and the solvent is evaporated to give N-allyl-5-azaisatoic anhydride.

후처리

  1. additionis added
  2. washthe organic layer is washed with water
  3. dry with materialdried (MgSO4)
  4. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-6d46e73ce85047f2bab5e918a410ba72
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193185B2

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