Anthranilic Acid → 5-Chloroisatoic anhydride

HRID 215793

반응식

HRID 215793 반응식
NC1C=CC=CC=1[C:4](O)=[O:5].[NH2:11][C:12]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:13]=1[C:14]([OH:16])=[O:15].ClC(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl>C1COCC1>[Cl:21][C:18]1[CH:17]=[C:13]2[C:14]([O:16][C:4](=[O:5])[NH:11][C:12]2=[CH:20][CH:19]=1)=[O:15]

참가 물질

5

반응물 3

HCID 227Anthranilic AcidHCID 124762-Amino-5-chlorobenzoic acidHCID 94429Triphosgene

생성물 1

HCID 784805-Chloroisatoic anhydride수율 89%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Isatoic anhydrides were prepared from 2-aminobenzoic acid derivatives using the following procedure. A solution of 2-amino-5-chlorobenzoic acid (1.56 g, 9.7 mmol) in 25 mL of dry THF and triphosgene (1.00 g, 3.3 mmol) was stirred at room temperature for 18 h. The resultant solid was filtered, washed with cold acetone, and dried under vacuum to give 1.56 g (89%) of 5-chloroisatoic anhydride.

후처리

  1. filtrationThe resultant solid was filtered
  2. washwashed with cold acetone
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-33d43fc23d5f47c2a0646fa1bb768808
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193185B2

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