Hydrochloric Acid → 4-(3-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride

HRID 215825

반응식

HRID 215825 반응식
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2(O)[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[ClH:18]>O>[ClH:18].[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 752554-[3-(Trifluoromethyl)phenyl]-4-piperidinol

생성물 1

HCID 234359914-(3-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a round-bottomed flask equipped with a mechanical stirrer, 50 g of 4-(3-trifluoromethylphenyl)-4-piperidinol are charged to 377 ml of water and 514 ml of concentrated hydrochloric acid. The mixture is left to react at reflux for 5 hours and is then cooled to ambient temperature. A white solid precipitates. It is filtered off through a Büchner funnel and dried in an oven. 37 g of a white solid are isolated. M.p. 203-204° C.

후처리

  1. customIn a round-bottomed flask equipped with a mechanical stirrer
  2. waitThe mixture is left
  3. customto react
  4. temperatureat reflux for 5 hours
  5. customA white solid precipitates
  6. filtrationIt is filtered off through a Büchner funnel
  7. customdried in an oven

출처 및 근거

ORD 기록
ord-8d33625c1f5646a4be3f592063add37e
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193190B2

연결된 노트

불러오는 중…