3-(Dimethylamino)phenol → HCID 58006189, 화합물

HRID 215913

반응식

HRID 215913 반응식
[CH3:1][N:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[CH:5]=1)[CH3:3].Cl[CH2:12][C:13]([N:15]([CH3:17])[CH3:16])=[O:14].C([O-])([O-])=O.[K+].[K+]>CS(C)=O.ClCCl>[CH3:1][N:2]([CH3:3])[C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:12][C:13]([N:15]([CH3:17])[CH3:16])=[O:14]

참가 물질

6

반응물 3

HCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 758862-chloro-N,N-dimethylacetamide

생성물 1

HCID 58006189HCID 58006189, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 6344Dichloromethane용매

실험 절차

To a mixture of 3-N,N-dimethylamino phenol (69) (3.43 g, 25 mmol) and 2-chloro N,N-dimethylacetamide (3.66 g, 30 mmol) in DMSO (30 mL) was added K2CO3 (6.7 g, 50 mmol) and the resulting suspension was stirred at room temperature for 16 h. The reaction was then diluted with dichloromethane (125 mL), and washed with water (2×100 mL), and brine (100 mL), and dried, and filtered, and the solvent was removed under vacuum. The crude product, Compound 70, was obtained as purple, thick oil that was used in the next step without additional purification.

후처리

  1. washwashed with water (2×100 mL), and brine (100 mL)
  2. customdried
  3. filtrationfiltered
  4. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-8c0bde69592943d7a6750f0b57894054
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193203B2

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