Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Bromoacetamide → 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Bromoacetamide | HCID 4353 | — |
| 반응물 | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 5380710 | 82% |
반응 단계
To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1.2 g, 7.8 mmol) in CH2Cl2 (25 mL) was added N-bromoacetamide (1.2 g, 8.7 mmol) in CH2Cl2 (25 mL). The reaction mixture was refluxed for 40 minutes, then concentrated and washed with cold water. The crude material was recrystallized from a minimal amount of isopropanol and dried under vacuum to give the title compound (82%) as light-gray solid. MS (ES+) [M+H]+=232.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08193202B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-fd79b2c07845414fba0e4c6477f390a4 |
| 출처 메모 | uspto-grants-2012_06 |