反应详情

To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1.2 g, 7.8 mmol) in CH2Cl2 (25 mL) was added N-bromoacetamide (1.2 g, 8.7 mmol) in CH2Cl2 (25 mL). The reaction mixture was refluxed for 40 minutes, then concentrated and washed with cold water. The crude material was recrystallized from a minimal amount of isopropanol and dried under vacuum to give the title compound (82%) as light-gray solid. MS (ES+) [M+H]+=232.

1. temperatureThe reaction mixture was refluxed for 40 minutes
2. concentrationconcentrated
3. washwashed with cold water
4. customThe crude material was recrystallized from a minimal amount of isopropanol
5. customdried under vacuum