Triethylamine → 1-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine	HCID 5380710	—
반응물	N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide	HCID 67036908	—
용매	Isopropanol	HCID 3776	—
생성물	1-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide	HCID 57920204	—

반응 조건

온도	100 °C

반응 단계

To a solution of N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide from example 1, step B, (36 mg, 0.1 mmol) in isopropanol (1 mL), was added to 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine from step A (24 mg, 0.1 mmol) and triethylamine (0.04 mL, 0.3 mmol). The reaction mixture was heated at 100° C. for 10 minutes under microwave condition, and then concentrated under vacuum. The product was isolated by prep HPLC to give the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08193202B2
출처 데이터셋	uspto-grants-2012_06
ORD ID	ord-7fa5a5f9536446e1947c6ee98c1af544
출처 메모	uspto-grants-2012_06