Hydrochloric Acid → Phthalylglycine aldehyde

HRID 216277

반응식

HRID 216277 반응식
C(O[C:4]1([O:14]CC)[NH:8][C:7](=[O:9])[C:6]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:5]12)C.Cl.[C:18](OCC)(=[O:20])[CH3:19]>O1CCCC1>[O:14]=[C:4]1[C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:7](=[O:9])[N:8]1[CH2:19][CH:18]=[O:20]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 66899166Phthalimide diethylacetal

생성물 1

HCID 76201Phthalylglycine aldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
75 °C

실험 절차

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to RT, and ethyl acetate (100 mL) was added. The solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL), and the organic layer was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

후처리

  1. temperatureto cool to RT
  2. extractionThe solution was extracted with saturated sodium carbonate solution (100 mL), brine (100 mL)
  3. customthe organic layer was separated
  4. dry with materialdried over magnesium sulfate (MgSO4)
  5. filtrationThe solution was filtered
  6. customevaporated

출처 및 근거

ORD 기록
ord-a990b9d9707c43e0b568c4def5e66c54
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193227B2

연결된 노트

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