1,2-Dimethoxyethane → HCID 11459000, 화합물

HRID 2163196노트

반응식

HRID 2163196 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH3:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.[OH-].[K+].C(COC)OC>O.CN(C)P(N(C)C)(N(C)C)=O>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:17][C:14]2[CH:15]=[CH:16][C:11]([O:10][CH3:9])=[CH:12][CH:13]=2)[N:3]=1

참가 물질

7

반응물 4

HCID 80711,2-DimethoxyethaneHCID 90154-MethoxyphenolHCID 14797Potassium HydroxideHCID 169892,6-Dichloropyridine

생성물 1

HCID 11459000HCID 11459000, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 12679Hexamethylphosphoramide용매

실험 절차

A solution comprising 14.8 grams (0.1 mole) of 2,6-dichloropyridine, 12.4 grams (0.1 mole) of 4-methoxyphenol and 8.4 grams (0.15 mole) of flake potassium hydroxide in 100 milliliters of a 1:1 mixture of monoglyme and hexamethylphosphoramide was stirred for 24 hours at room temperature. The resulting mixture was diluted with water and thoroughly extracted with hexane. The extract was washed with water, dried and concentrated under reduced pressure. The residue was recrystallized from pentane giving 14.5 grams (64 percent of theoretical) of 2-chloro-6-(4-methoxyphenoxy)pyridine which melted at 63°-65° C.

후처리

  1. extractionthoroughly extracted with hexane
  2. washThe extract was washed with water
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized from pentane giving 14.5 grams (64 percent of theoretical) of 2-chloro-6-(4-methoxyphenoxy)pyridine which melted at 63°-65° C.

출처 및 근거

ORD 기록
ord-0a5fe9ba39a5445fa67a3a082a64c74a
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04132783

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