Water → 3,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide

HRID 2163520노트

반응식

HRID 2163520 반응식
[C:1]([CH:4]([C:14](=O)[CH3:15])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6])(=O)[CH3:2].O.[NH2:18][NH2:19].O>C(O)(=O)C>[CH3:2][C:1]1[C:4]([C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])=[C:14]([CH3:15])[NH:19][N:18]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 22033802HCID 22033802, 화합물

생성물 1

HCID 107038853,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The foregoing diacetyl acetanilide (2.2 g) in glacial acetic acid (30 ml) was treated with hydrazine hydrate (1.5 g) and the mixture boiled under reflux for 30 min. The mixture was then poured into water and the product collected and crystallised from ethanol. 3,5-dimethyl-N-phenyl-4-pyrazolecarboxamide (1.9 g, 86%) was obtained as colourless plates, m.p. 244-5° C (Found: C, 66.8 H, 6.0 N, 19.3 C12H13N3O requires C, 66.9; H, 6.1; N, 19.5%).

후처리

  1. temperatureunder reflux for 30 min
  2. customthe product collected
  3. customcrystallised from ethanol

출처 및 근거

ORD 기록
ord-fafb41a2053543a0be3cc30d3ef182a7
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04134987

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