Hydrochloric Acid → 2-(Phenethylhydrazono)-propionic acid

HRID 2163684노트

반응식

HRID 2163684 반응식
[CH2:1]([NH:9][N:10]=[C:11]([CH3:17])[C:12]([O:14]CC)=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[K+].C(O)C.Cl>C(OCC)C.O>[CH2:1]([NH:9][N:10]=[C:11]([CH3:17])[C:12]([OH:14])=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 73183671Ethyl 2-(phenethylhydrazono)-propionate

생성물 1

HCID 1942362-(Phenethylhydrazono)-propionic acid수율 47%

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

6 g. Ethyl 2-(phenethylhydrazono)-propionate (prepared according to Example 2) are dissolved in a solution of 1.4 g. potassium hydroxide in 28 ml. 80% ethanol and saponified at ambient temperature. After stirring for 30 hours, the reaction mixture is mixed with 25 ml. water and shaken out twice with 50 ml. amounts of diethyl ether. The aqueous phase is acidified with dilute hydrochloric acid. The crystals which precipitate out are filtered off and recrystallized from toluene. There is obtained 2-(phenethylhydrazono)-propionic acid in a yield of 47% of theory; m.p. 74°-76° C.

후처리

  1. customsaponified at ambient temperature
  2. additionthe reaction mixture is mixed with 25 ml
  3. customThe crystals which precipitate out
  4. filtrationare filtered off
  5. customrecrystallized from toluene

출처 및 근거

ORD 기록
ord-5d37c66fcbf04311a25a4636bf89f1cc
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04136196

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