Hydrochloric Acid → Methyl 4-bromo-alpha-hydroxybenzeneacetate

HRID 216414

반응식

HRID 216414 반응식
Cl.[Br:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1.[CH3:14]O>>[Br:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([O:10][CH3:14])=[O:9])=[CH:5][CH:4]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 97930p-Bromomandelic acid

생성물 1

HCID 14571696Methyl 4-bromo-alpha-hydroxybenzeneacetate

실험 절차

Hydrogen chloride (4 M in 1,4-dioxane) (3 mL, 18 mmol) was added to an ambient temperature solution of 4-bromomandelic acid (5 g, 21.6 mmol) in methanol (50 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford methyl (4-bromophenyl)(hydroxy)acetate which was used in the subsequent step without further purification.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-533bddb034934f46ba8c10cbee45ebb7
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193228B2

연결된 노트

불러오는 중…