Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → Amoxicillin Dimethyl Sulfoxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Amoxicillin | HCID 33613 | — |
| 반응물 | Amoxicillin Trihydrate | HCID 62883 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Amoxicillin Dimethyl Sulfoxide | HCID 70528119 | — |
반응 단계
Fifty grams of amoxicillin trihydrate is added in portions, with stirring, to 375 ml. of dimethyl sulfoxide. The mixture is stirred at room temperature for 2 hours, then diluted with 75 ml. of methylene chloride and cooled to 0°-5°. The solid product is collected by filtration, washed with methylene chloride and dried. Analysis shows 3 moles of dimethyl sulfoxide and 0.5 mole of water for each mole of amoxicillin; formula weight = 609.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04137408 |
| 출처 데이터셋 | uspto-grants-1979_01 |
| ORD ID | ord-ab0d6adfd6ae4b359a4a95dd9daafca8 |
| 출처 메모 | uspto-grants-1979_01 |