Hydrochloric Acid → 7-(2-Fluorobenzoyl)-indolin-2-one

HRID 2164299노트

반응식

HRID 2164299 반응식
[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]2SC)=[O:5].[Sn].Cl>C(O)C>[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11]2)=[O:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 133942837-(2-Fluorobenzoyl)-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 133942867-(2-Fluorobenzoyl)-indolin-2-one수율 60.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 60 g (0.2 mole) of 7-(2-fluorobenzoyl)-3-methylthioindolin-2-one and 60 g (0.5 mole) of tin powder in one liter of 95% ethanol was heated to reflux and 150 ml of concentrated hydrochloric acid was added. Heating was continued for 18 hrs, then the mixture was cooled and the precipitate was collected by decanting the slurry from the remaining tin and filtering the slurry. The filter cake was recrystallized twice from absolute ethanol to give 31 g (60%) white needles, m.p. 209°-210° C.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureHeating
  4. temperaturethe mixture was cooled
  5. customthe precipitate was collected
  6. customby decanting the slurry from the remaining tin
  7. filtrationfiltering the slurry
  8. customThe filter cake was recrystallized twice from absolute ethanol

출처 및 근거

ORD 기록
ord-9c96ec57725541ba8227d135cad2204b
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04503073

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