Methanol → 4-[5-(1-Imidazolylmethyl)-thien-2-yl]-4-oxobutyric acid

HRID 2164395노트

반응식

HRID 2164395 반응식
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][C:6]([C:8]1[S:9][C:10]([CH2:13][C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)=[CH:11][CH:12]=1)=[O:7].[OH-].[Na+].CO>O>[NH:18]1[CH:17]=[CH:16][N:15]=[C:14]1[CH2:13][C:10]1[S:9][C:8]([C:6](=[O:7])[CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 704876864-[5-(1-Imidazolylmethyl)-thien-2-yl]-4-oxo-butyric acid methyl ester

생성물 1

HCID 704292984-[5-(1-Imidazolylmethyl)-thien-2-yl]-4-oxobutyric acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4.17 g of 4-[5-(1-imidazolylmethyl)-thien-2-yl]-4-oxo-butyric acid methyl ester, 0.8 g of sodium hydroxide and 20 ml of methanol is stirred at room temperature for 8 hours. The solvent is then stripped off and the residue is taken up in water. The solution is extracted several times with chloroform, and the chloroform phase is discarded. The aqueous solution is brought to about pH 7 with dilute hydrochloric acid and is concentrated to dryness. The residue is purified by column chromatography (silica gel/CHCl3 /methanol).

후처리

  1. extractionThe solution is extracted several times with chloroform
  2. concentrationis concentrated to dryness
  3. customThe residue is purified by column chromatography (silica gel/CHCl3 /methanol)

출처 및 근거

ORD 기록
ord-ec16d96664ce4c5a8672c2a1e115f8be
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04504479

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