Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Fluoro-6-(phenylamino)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 2,6-Difluorobenzonitrile | HCID 74695 | — |
| 생성물 | 2-Fluoro-6-(phenylamino)benzonitrile | HCID 13469799 | — |
반응 단계
A mixture of 2.8 g (20 mmol) of 2,6-difluorobenzonitrile in 20 ml of aniline is refluxed for 6 hrs. The mixture is poured into diluted HCl and the acid is extracted with methylene chloride. Evaporation gives the crude product which is chromatographed on silica gel (50% hexane--CH2Cl2) to give the title compound, m.p. 97°-99° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04504660 |
| 출처 데이터셋 | uspto-grants-1985_03 |
| ORD ID | ord-30c1ed890d374469b34a85c512485c68 |
| 출처 메모 | uspto-grants-1985_03 |