2-Chloro-5-(trifluoromethyl)pyridine → 2-Chloro-5-trichloromethylpyridine

HRID 2164453

반응식

HRID 2164453 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](F)(F)F)=[CH:4][N:3]=1.[Cl-:12].[Al+3].[Cl-:14].[Cl-:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([Cl:15])([Cl:14])[Cl:12])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 502932-Chloro-5-trichloromethylpyridine

실험 절차

To 18.2 g of 2-chloro-5-trifluoromethyl pyridine, 20 g of aluminum chloride was added in 2 hours, and they were reacted under the predetermined reaction conditions as shown in Table 1. After the completion of the reaction, the reaction product was cooled and then introduced into ice water, and the oil layer was separated by liquid separation. The solvent was removed by distillation to obtain 2-chloro-5-trichloromethyl pyridine.

후처리

  1. customthey were reacted under the predetermined reaction conditions
  2. customAfter the completion of the reaction
  3. temperaturethe reaction product was cooled
  4. customthe oil layer was separated by liquid separation
  5. customThe solvent was removed by distillation

출처 및 근거

ORD 기록
ord-d59167c8efd6400badb46632f1a2389d
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04504665

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