Water → N,N-Dimethyl-N'-(6-allyloxybenzothiazole-2-sulfonyl)formamidine

HRID 2164614노트

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HRID 2164614 반응식
[CH3:1][N:2]([CH3:18])[CH:3]=[N:4][S:5]([C:8]1[S:9][C:10]2[CH:16]=[C:15]([OH:17])[CH:14]=[CH:13][C:11]=2[N:12]=1)(=[O:7])=[O:6].[CH2:19](Br)[CH:20]=[CH2:21].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[CH3:1][N:2]([CH3:18])[CH:3]=[N:4][S:5]([C:8]1[S:9][C:10]2[CH:16]=[C:15]([O:17][CH2:21][CH:20]=[CH2:19])[CH:14]=[CH:13][C:11]=2[N:12]=1)(=[O:6])=[O:7]

참가 물질

6

반응물 4

HCID 962WaterHCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 54375873N,N-Dimethyl-N'-(6-hydroxybenzothiazole-2-sulfonyl)formamidine

생성물 1

HCID 53647804N,N-Dimethyl-N'-(6-allyloxybenzothiazole-2-sulfonyl)formamidine수율 70.7%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

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온도
60 °C

실험 절차

A solution of product from Step A (1.14 gm, 4.0 mmol) and allyl bromide (0.5 mL, 5.5 mmol) in dimethyl sulfoxide (8 mL) containing potassium carbonate (0.75 gm, 5.4 mmol) was warmed at 60° C. for 15-20 hours. The reaction mixture was poured into water and the product was extracted into ethyl acetate, dried (Na2SO4) and evaporated to give a viscous oil (0.92 gm).

후처리

  1. extractionthe product was extracted into ethyl acetate
  2. dry with materialdried (Na2SO4)
  3. customevaporated

출처 및 근거

ORD 기록
ord-b236e1d2d20647fe8b9d12df24171e7a
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04505923

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