Hydrogen Bromide → Phenol, 4-(4-(methylsulfonyl)phenoxy)-

HRID 2164642

반응식

HRID 2164642 반응식
[CH3:1][S:2]([C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].Br>C(O)(=O)C>[CH3:1][S:2]([C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 514881Benzene, 1-methoxy-4-(4-(methylsulfonyl)phenoxy)-

생성물 1

HCID 514882Phenol, 4-(4-(methylsulfonyl)phenoxy)-수율 98.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 37.3 g of 4-(4-(methylsulfonyl)phenoxy)-1-methoxybenzene (Example 18), 41 ml of 48% aqueous hydrogen bromide and 185 ml of glacial acetic acid was heated at reflux under nitrogen for 21 hrs. The reaction mixture was cooled and the solvent removed in vacuo. The product was collected by filtration, washed well with water and dried, which gave 35.0 g (98.9% yield) of the product. Recrystallization from aqueous ethanol gave purified 4-(4-(methylsulfonyl)phenoxy)phenol, mp 129°-130° C.

후처리

  1. temperatureat reflux under nitrogen for 21 hrs
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent removed in vacuo
  4. filtrationThe product was collected by filtration
  5. washwashed well with water
  6. customdried

출처 및 근거

ORD 기록
ord-76d78786cedf40808e47d51e708b1537
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04505929

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