Chlorine → 1-(5-Chloro-2,4-dihydroxy-3-propylphenyl)ethanone
반응식
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([OH:11])[CH:5]=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13].[Cl:15]Cl>C(Cl)(Cl)Cl>[Cl:15][C:5]1[C:6]([OH:11])=[C:7]([CH2:8][CH2:9][CH3:10])[C:2]([OH:1])=[C:3]([C:12](=[O:14])[CH3:13])[CH:4]=1참가 물질
4
실험 절차
To a solution of 5.0 g (0.026 mol) of 1-(2,4-dihydroxy-3-propylphenyl)ethanone in 125 ml of chloroform was added 32.3 ml of (0.030 mol) 0.94M chlorine in chloroform dropwise at 25°. The mixture was stirred at 25° for 2.5 hours. The solvent was removed in vacuo and the residue was extracted with hot hexane. The hexane extract was boiled down to 100 ml and allowed to crystallize. Filtration gave 3.0 g, melting point 96°. (51% yield) of 1-(5-chloro-2,4-dihydroxy-3-propylphenyl)ethanone.
후처리
- customThe solvent was removed in vacuo
- extractionthe residue was extracted with hot hexane
- extractionThe hexane extract
- customto crystallize
- filtrationFiltration
- customgave 3.0 g, melting point 96°
출처 및 근거
- ORD 기록
- ord-5438da4e9d554873aa15eea64d3849a9
- 출처 데이터셋
- uspto-grants-1985_03
- 특허 번호
- US04507498
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