Sodium Cyanide → 2-(6-Methoxyindan-1-yl)acetonitrile
반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[CH2:12]OS(C)(=O)=O)=[CH:5][CH:4]=1.[C-:18]#[N:19].[Na+]>CS(C)=O>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[CH2:12][C:18]#[N:19])=[CH:5][CH:4]=1참가 물질
4
실험 절차
12.8 g (50 mmol) of methanesulphonic acid (6-methoxyindan-1-ylmethyl) ester and 3.7 g (75 mmol) of sodium cyanide are dissolved in 70 ml of dimethyl sulphoxide and heated at 80° for 6 hours. The reaction mixture is poured onto 200 ml of ice-water and extracted three times by shaking with 100 ml of toluene each time. The organic phases are combined, subsequently washed with saturated sodium chloride solution and dried over magnesium sulphate. After removing the solvent in vacuo, crude 2-(6-methoxyindan-1-yl)acetonitrile is obtained.
후처리
- temperatureheated at 80° for 6 hours
- extractionextracted three times
- washsubsequently washed with saturated sodium chloride solution
- dry with materialdried over magnesium sulphate
- customAfter removing the solvent in vacuo
출처 및 근거
- ORD 기록
- ord-a952fad7214e4c9c80c6de6fb950f446
- 출처 데이터셋
- uspto-grants-1990_07
- 특허 번호
- US04939160
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