Hydrochloric Acid → 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

HRID 2165415노트

반응식

HRID 2165415 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[CH:7][CH:8]=1.[CH3:11][C:12](=[N:16][OH:17])[C:13](=O)[CH3:14].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:13]([CH3:14])=[C:12]([CH3:11])[N+:16]=2[O-:17])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312444-MethoxybenzaldehydeHCID 63989692-Oxime 2,3-butanedione

생성물 1

HCID 200640232-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 68.07 g of anisaldehyde, 50.5 g of 2,3-butanedione mono-oxime and 150 ml of acetic acid was saturated with hydrogen chloride gas and the mixture was allowed to stand at room temperature for 3 hours. The solid product was collected and recrystallized from methanol to give 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride, m.p. 194°-196° C. The latter was converted to the free base for use in the next reaction by treatment with sodium bicarbonate solution.

후처리

  1. customThe solid product was collected
  2. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-2bcec526929f41eb9074f46939f94257
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939267

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