홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Water → N'-t-butyl-N-(4-methylbenzoyl)-N'-(2,5-dichlorothiophene-3-carbonyl)hydrazine

HRID 21658
노트
인쇄 미리보기

반응식

HRID 21658 반응식
[C:1]([NH:5][NH:6][C:7](=[O:15])[C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].O.[OH-].[Na+].[Cl:19][C:20]1[S:21][C:22]([Cl:28])=[CH:23][C:24]=1[C:25](Cl)=[O:26]>C1(C)C=CC=CC=1.CCOCC>[C:1]([N:5]([C:25]([C:24]1[CH:23]=[C:22]([Cl:28])[S:21][C:20]=1[Cl:19])=[O:26])[NH:6][C:7](=[O:15])[C:8]1[CH:9]=[CH:10][C:11]([CH3:14])=[CH:12][CH:13]=1)([CH3:4])([CH3:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 27770842,5-Dichlorothiophene-3-carbonyl chlorideHCID 15452037N'-t-butyl-N-4-methylbenzoylhydrazine

생성물 1

HCID 15452005N'-t-butyl-N-(4-methylbenzoyl)-N'-(2,5-dichlorothiophene-3-carbonyl)hydrazine

시약·촉매·용매 2

HCID 1140
Toluene
용매
HCID 3283Diethyl Ether용매

실험 절차

N'-t-butyl-N-4-methylbenzoylhydrazine (0.7 g) was dissolved in 35 ml toluene. Water (5 ml) and 50% aqueous sodium hydroxide (0.8 g) were added followed by 2,5-dichlorothiophene-3-carbonylchloride (2.0 g). After stirring for 3 hours at room temperature, ether was added and the organic layer separated. Evaporation afforded a solid which was triturated with 10% ether-hexane to afford N'-t-butyl-N-(4-methylbenzoyl)-N'-(2,5-dichlorothiophene-3-carbonyl)hydrazine: m.p. 163°-165° C.

후처리

  1. customthe organic layer separated
  2. customEvaporation
  3. customafforded a solid which
  4. customwas triturated with 10% ether-hexane

출처 및 근거

ORD 기록
ord-49ad8bc984b144d89e93650c517555c4
출처 데이터셋
uspto-grants-1995_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05424333

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트