Hydrochloric Acid → E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene

HRID 2165982노트

반응식

HRID 2165982 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:14](O)[CH:15]=[CH2:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:18].O>C(OCC)C>[O:1]([C:8]1[CH:9]=[C:10](/[CH:14]=[CH:15]/[CH2:16][Cl:18])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 129613931-(3-Phenoxyphenyl)prop-2-en-1-ol

생성물 1

HCID 19915310E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

1-(3-Phenoxyphenyl)prop-2-en-1-ol (0.05 g) was dissolved in diethyl ether (2 cm3) which had been previously saturated with hydrogen chloride gas, and the solution was stirred at the ambient temperature for 2 hours. Water was added to the mixture and the products extracted into further diethyl ether. The combined ethereal layers were dried over anhydrous magnesium sulphate and the solvent evaporated under reduced pressure. The residual oil was purified by column chromatography on a silica gel support, eluted with hexane containing 5% by volume ethyl acetate, to give E-3-(3-phenoxyphenyl)-1-chloroprop-2-ene (0.03 g).

후처리

  1. extractionthe products extracted into further diethyl ether
  2. dry with materialThe combined ethereal layers were dried over anhydrous magnesium sulphate
  3. customthe solvent evaporated under reduced pressure
  4. customThe residual oil was purified by column chromatography on a silica gel support
  5. washeluted with hexane containing 5% by volume ethyl acetate

출처 및 근거

ORD 기록
ord-da8a4d9f1bd3466888da9a1eb04a0075
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04942264

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