HCID 14990558, 화합물 → HCID 14990559, 화합물

HRID 2166030노트

반응식

HRID 2166030 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH:17]([CH3:19])[CH3:18])=[C:12]([N+:20]([O-])=O)[CH:11]=2)=[O:9])=[CH:4][CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:20][C:12]1[CH:11]=[C:10]([C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:9])[CH:15]=[CH:14][C:13]=1[NH:16][CH:17]([CH3:18])[CH3:19]

참가 물질

5

반응물 2

HCID 14990558HCID 14990558, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 14990559HCID 14990559, 화합물수율 92.1%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A solution of 14.7 parts of (4-fluorophenyl) [4-[(1-methylethyl)amino]-3-nitrophenyl]methanone in 120 parts of ethanol was hydrogenated at 2.105Pa with 3 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated, yielding 12.3 parts (92.1%) of [3-amino-4-[(1-methylethyl)amino]phenyl](4-fluorophenyl)methanone as a residue (int. 2).

후처리

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-d6ffda214e844c3480bb33dc11040f14
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04943574

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