Potassium Carbonate → 4-Methoxymethyl-5-phenoxy-beta-carboline-3-carboxamidoxime

HRID 2166362노트

반응식

HRID 2166362 반응식
[C:1]([C:3]1[N:4]=[CH:5][C:6]2[NH:7][C:8]3[C:13]([C:14]=2[C:15]=1[CH2:16][O:17][CH3:18])=[C:12]([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:11]=[CH:10][CH:9]=3)#[N:2].Cl.[NH2:27][OH:28].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:18][O:17][CH2:16][C:15]1[C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][C:12]=3[O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:7][C:6]=2[CH:5]=[N:4][C:3]=1[C:1](=[N:27][OH:28])[NH2:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 230394773-Cyano-4-methoxymethyl-5-phenoxy-beta-carboline

생성물 1

HCID 1362106304-Methoxymethyl-5-phenoxy-beta-carboline-3-carboxamidoxime

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 329 mg (0.001 mol) of 3-cyano-4-methoxymethyl-5-phenoxy-beta-carboline, 100 mg of hydroxylamine hydrochloride, 20 ml of ethanol (99%) and 0.52 ml of a 20% aqueous potassium carbonate solution is refluxed for 22 hours. The reaction mixture is filtered and the filtrate concentrated. The residue is mixed with 10 ml of water, the crystalline solid is filtered off and washed with water.

후처리

  1. temperatureis refluxed for 22 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate concentrated
  4. additionThe residue is mixed with 10 ml of water
  5. filtrationthe crystalline solid is filtered off
  6. washwashed with water

출처 및 근거

ORD 기록
ord-6e26e0cbcdb34cd8a2d3ac2635446be7
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04945090

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