Ethanol → Methyl n,n'-diphenylcarbamimidothioate

HRID 2166543노트

반응식

HRID 2166543 반응식
[CH:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[S:9])=[CH:3][CH:2]=1.CI.[CH2:19](O)C>O>[CH3:19][S:9][C:8](=[N:7][C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 6328Methyl iodideHCID 700999Diphenylthiourea

생성물 1

HCID 221767Methyl n,n'-diphenylcarbamimidothioate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 2 l flask were added 342 g of thiocarbanilide, 240 g of methyl iodide and 350 cc of ethanol and the mixture was refluxed for 2 hours. After cooling the mixture to a room temperature, a small amount of water was added and the mixture was allowed to stand to precipitate the raw product, which was then filtered off and dissolved in 12 l of hot water. After filtration, the filtrate was converted to an alkaline solution by addition of NaOH to precipitate the product. The product was filtered and washed well until the filtrate became neutral. After drying, the product was recrystalized in 1 l of ethanol to give S-methyl-N,N'-diphenylisothiourea.

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. customto precipitate the raw product, which
  3. filtrationwas then filtered off
  4. dissolutiondissolved in 12 l of hot water
  5. filtrationAfter filtration
  6. additionthe filtrate was converted to an alkaline solution by addition of NaOH
  7. customto precipitate the product
  8. filtrationThe product was filtered
  9. washwashed well until the filtrate
  10. customAfter drying
  11. customthe product was recrystalized in 1 l of ethanol

출처 및 근거

ORD 기록
ord-1105de70bcdf44d48bde246d90b98bbd
출처 데이터셋
uspto-grants-1983_06
특허 번호
US04387150

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