Sodium Hydroxide → 4-Methyl-3-cyclohexene-1-carboxylic Acid

HRID 2166859노트

반응식

HRID 2166859 반응식
[OH-].[Na+].[CH3:3][CH:4]1[CH2:9][CH2:8][C:7]([C:10]([OH:12])=[O:11])=[CH:6][CH2:5]1>O>[CH3:3][C:4]1[CH2:9][CH2:8][CH:7]([C:10]([OH:12])=[O:11])[CH2:6][CH:5]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 2193894-Methylcyclohex-1-ene-1-carboxylic acid

생성물 1

HCID 203504-Methyl-3-cyclohexene-1-carboxylic Acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into 1 liter reaction flask equipped with stirrer, thermometer reflux condenser and heating mantle is placed 100 ml anhydrous methyl, 1.25 moles (100 grams) of 50% aqueous NaOH solution, 100 ml water and 154 grams (1 mole) of the methyl ester of 4-methyl-cyclohexene-1-carboxylic acid. The reaction mass is stirred for a period of 5 hours at room temperature and then extracted with 1 volume of diethyl ether. The aqueous layer is set aside with 10% hydrochloric acid and extracted with diethyl ether. The diethyl ether extracts are washed with saturated sodium chloride solution and the ether is evaporated yielding 100.5 grams of solid melting at 95° C. This material is the carboxylic acid having the structure: ##STR42## as confirmed by NMR and IR analysis.

후처리

  1. customInto 1 liter reaction flask
  2. customequipped with stirrer, thermometer reflux condenser
  3. temperatureheating mantle
  4. extractionextracted with 1 volume of diethyl ether
  5. extractionextracted with diethyl ether
  6. washThe diethyl ether extracts are washed with saturated sodium chloride solution
  7. customthe ether is evaporated

출처 및 근거

ORD 기록
ord-dcb04eac26a54c1da2d8cb573d4e3f88
출처 데이터셋
uspto-grants-1983_06
특허 번호
US04390434

반응 노트

불러오는 중…