Chloroacetaldehyde → HCID 90427811, 화합물
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[NH2:1][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[C:4]#[N:5].Cl[CH2:13][CH:14]=O>O>[CH3:10][C:8]1[N:9]2[CH:13]=[CH:14][N:1]=[C:2]2[C:3]([C:4]#[N:5])=[C:6]([CH3:11])[CH:7]=1참가 물질
4
실험 절차
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80 oC for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
후처리
- temperaturewas heated at 80 oC for 16 h
- customOn completion, it was quenched by 1N NaOH till pH 8
- customSolid precipitated
- filtrationwas filtered
- customvacuum dried
출처 및 근거
- ORD 기록
- ord-44a3673fc57c4ef3b2740055c7d326b1
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09045477B2
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