2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221, 화합물

HRID 2167684노트

반응식

HRID 2167684 반응식
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

참가 물질

5

반응물 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

생성물 1

HCID 44119221HCID 44119221, 화합물

시약·촉매·용매 3

HCID 935Nickel촉매HCID 222Ammonia용매HCID 887Methanol용매

실험 절차

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

후처리

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-08b61626b11249f295c4aeb7010332f1
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045477B2

반응 노트

불러오는 중…