Hydrochloric Acid → HCID 11845779, 화합물
반응식
[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12.[ClH:15]>CCO.[Pd]>[ClH:15].[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12참가 물질
5
실험 절차
10% Pd/C (40 mg) was added to a solution of ethyl imidazo[1,2-a]pyrazine-2-carboxylate (410 mg, 2.15 mmol) and conc.HCl (0.5 mL) in EtOH (9.5 mL) and stirring was continued under a hydrogen atmosphere for 16 h. The reaction mixture was filtered over a celite bed and the filtrate was concentrated under reduced pressure to afford the crude product, which was purified by washing with diethyl ether and dried to afford 400 mg of the title compound as a yellow hygroscopic solid.
후처리
- filtrationThe reaction mixture was filtered over a celite bed
- concentrationthe filtrate was concentrated under reduced pressure
- customto afford the crude product, which
- customwas purified
- washby washing with diethyl ether
- customdried
출처 및 근거
- ORD 기록
- ord-d14bb2a2bfff4b45843e094fdc4902f4
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09045479B2
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