Dimethylformamide diethylacetal → 7-benzyl-octahydro-5H,9bH-2a,4a,7,9a-tetraazacycloocta[cd]pentalene

HRID 21679

반응식

HRID 21679 반응식
[CH2:1]([N:8]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15][NH:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20](OC(OCC)N(C)C)C>C1C=CC=CC=1>[CH2:1]([N:8]1[CH2:19][CH2:18][N:17]2[CH2:16][CH2:15][N:14]3[CH2:13][CH2:12][N:11]([CH:20]23)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 70913Dimethylformamide diethylacetalHCID 100840821-Benzyl-1,4,7,10-tetraazacyclododecane

생성물 1

HCID 109676597-benzyl-octahydro-5H,9bH-2a,4a,7,9a-tetraazacycloocta[cd]pentalene수율 96%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 1-benzyl-1,4,7,10-tetraazacyclododecane (4 g; 0.015 mol) and dimethylformamide diethylacetal (6.88 g; 0.0467 mol) in benzene (40 ml) is heated at 80 C. and the azeotropic mixture ethanol-benzene is distilled away. When the conversion is ended, the solvent is evaporated under reduced pressure and the final product is obtained as a yellow oil (4.0 g). Yield 96%

후처리

  1. distillationand the azeotropic mixture ethanol-benzene is distilled away
  2. customthe solvent is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-45ff071bbebe4e44a0b56ce40e0262de
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424423

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