4-[3-(Dimethylamino)propoxy]benzonitrile → 4-[3-(Dimethylamino)propoxy]benzylamine

HRID 2168035노트

반응식

HRID 2168035 반응식
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>CO.[Ni]>[NH2:12][CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:15])=[CH:14][CH:13]=1

참가 물질

4

반응물 1

HCID 118583624-[3-(Dimethylamino)propoxy]benzonitrile

생성물 1

HCID 214653844-[3-(Dimethylamino)propoxy]benzylamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

후처리

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-0d3d4d386feb4faabda01e1db0770d9c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045475B2

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