Sodium hydride → HCID 178514754, 화합물

HRID 2168087노트

반응식

HRID 2168087 반응식
[Si]([O:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][OH:16])[CH2:11][CH2:10]1)(C(C)(C)C)(C)C.[Cl:17][C:18]1[CH:19]=[C:20]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=1F.[H-].[Na+]>O1CCCC1>[Cl:17][C:18]1[CH:19]=[C:20]([S:25]([NH2:28])(=[O:26])=[O:27])[CH:21]=[CH:22][C:23]=1[O:16][CH2:15][C@H:12]1[CH2:11][CH2:10][C@H:9]([OH:8])[CH2:14][CH2:13]1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 75098833-Chloro-4-fluorobenzenesulfonamideHCID 178455322HCID 178455322, 화합물

생성물 1

HCID 178514754HCID 178514754, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(Trans-4-(tert-butyldimethylsilyloxy)cyclohexyl)methanol (275 mg, prepared according to a procedures in WO 2008/124878) and 3-chloro-4-fluorobenzenesulfonamide (259 mg) in tetrahydrofuran (15 mL) were treated with sodium hydride (180 mg, 60%) overnight. The reaction was quenched with water (1 mL) and trifluoroacetic acid (4 mL) was added. The resulting mixture was stirred for 1 hour and concentrated. The residue was triturated with water and methanol to provide the title compound.

후처리

  1. customThe reaction was quenched with water (1 mL) and trifluoroacetic acid (4 mL)
  2. additionwas added
  3. concentrationconcentrated
  4. customThe residue was triturated with water and methanol

출처 및 근거

ORD 기록
ord-28ec475ead5c47ce9310044bcce47bdf
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045475B2

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