HCID 610084, 화합물 → Methyl 3-phenyl-1-adamantaneacetate

HRID 21682

반응식

HRID 21682 반응식
[C:1]1([C:7]23[CH2:16][CH:11]4[CH2:12][CH:13]([CH2:15][C:9]([CH2:17][C:18]([OH:20])=[O:19])([CH2:10]4)[CH2:8]2)[CH2:14]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:22]12CC3CC(CC(CC(OC)=O)(C3)C1)C2.[Cl-].[Cl-].[Cl-].[Al+3]>C1C=CC=CC=1>[C:1]1([C:7]23[CH2:16][CH:11]4[CH2:12][CH:13]([CH2:15][C:9]([CH2:17][C:18]([O:20][CH3:22])=[O:19])([CH2:10]4)[CH2:8]2)[CH2:14]3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 610084HCID 610084, 화합물HCID 2771107(3-Phenyl-1-adamantyl)acetic acidHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 53665692Methyl 3-phenyl-1-adamantaneacetate

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Preparation of 3-Phenyl-l-adamantaneacetic acid, a hapten. Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

후처리

  1. customThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
  2. customThe layers were separated
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-4e36a21ee6d845b586893d9fe90a7e86
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424414

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