1,4-Dibromobutane → 1-(4-Chlorophenyl)cyclopentanecarbonitrile

HRID 2169149

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.Br[CH2:12][CH2:13][CH2:14][CH2:15]Br.C1(C2(C#N)CCCC2)C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:9]#[N:10])[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 80561,4-Dibromobutane

HCID 661681-Phenylcyclopentanecarbonitrile

HCID 2415824-Chlorobenzyl cyanide

생성물 1

HCID 973841-(4-Chlorophenyl)cyclopentanecarbonitrile수율 94%

실험 절차

1-(4-chlorophenyl)-cyclopentanecarbonitrile (21-02) (32.01 g, 94%) was synthesized as a yellow liquid from (4-chlorophenyl)-acetonitrile (19-02) (25 g, 165.56 mmol) and 1,4-dibromo-butane (20) (19.7 mL, 165.56 mmol) following the procedure as described for 1-phenyl-cyclopentanecarbonitrile (21-01).

출처 및 근거

ORD 기록: ord-fde9c76ba284485cbe2a9ba05fc27aea
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09045486B2

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