1,4-Dibromobutane → 1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile

반응식

[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH2:13][C:14]#[N:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Br[CH2:19][CH2:20][CH2:21][CH2:22]Br.FC(F)(F)C1C=CC(C2(C#N)CCCC2)=CC=1>>[F:1][C:2]([F:16])([F:17])[C:3]1[CH:4]=[C:5]([C:13]2([C:14]#[N:15])[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

참가 물질

반응물 3

HCID 80561,4-Dibromobutane

HCID 603657(3,5-Bis(trifluoromethyl)phenyl)acetonitrile

HCID 218996241-(4-(Trifluoromethyl)phenyl)cyclopentanecarbonitrile

생성물 1

HCID 102671981-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile

실험 절차

1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbonitrile (455) was synthesized from 2-(3,5-bis(trifluoromethyl)phenyl)acetonitrile (454) and 1,4-dibromobutane following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbonitrile (237).

출처 및 근거

ORD 기록: ord-45278e337cb4481b8345cd07f9330637
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09045486B2

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